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CS-W001157 4
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2-Methylpyridin-3-amine

  • CAS No. 3430-10-2

  • Cat. No. CS-W020092
  • Purity≥98%
  • MDL No.MFCD03788195

*For research and further manufacturing use only, not for direct human use.

2-Methylpyridin-3-amine|CS-W020092

Structure of 3430-10-2

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General Information

  • CAS No. 3430-10-2
  • Cat. No. CS-W020092
  • Purity ≥98%
  • MDL No. MFCD03788195
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂
  • Molecular Weight 108.14
  • Synonym(s) 3-Pyridinamine, 2-methyl-
  • SMILES NC1=CC=CN=C1C

Description

2-Methylpyridin-3-amine delivers a sterically accessible pyridyl amine scaffold with enhanced solubility and stability under standard conditions. This bench-stable heterocycle features a para-oriented amino group flanked by a methyl substituent, enabling efficient coupling in transition-metal-catalyzed transformations. The electron-rich nitrogen moiety facilitates coordination in catalytic systems and supports incorporation into bioactive molecules.

Application

2-Methylpyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of nitrogen-containing heterocycles. Its pyridine core offers predictable reactivity in palladium-catalyzed couplings, while the ortho-methyl group enhances metabolic stability and modulates electronic properties. The primary amine facilitates derivatization via acylation, alkylation, or coupling reactions, and the compound exhibits excellent bench stability and ease of purification—ideal for scalable synthesis and high-throughput screening applications.

Synthesis

  • Route1

    References

    • Rasala, D. Bulletin de la Societe Chimique de France, 1992 , # 1 p. 79 - 84
  • Route2

    References

    • Timperley, Christopher M.; Banks, R. Eric; Young, Ian M.; Haszeldine, Robert N. Journal of Fluorine Chemistry, 2011 , vol. 132, # 8 p. 541 - 547
  • Route3

    References

    • Niu, Chuansheng; Li, Jun; Doyle, Terrence W.; Chen, Shu-Hui Tetrahedron, 1998 , vol. 54, # 23 p. 6311 - 6318

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   0.97222
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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