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CS-W001157 4
Total: USD 88.00

4-(4-Fluorophenoxy)piperidine

  • CAS No. 3413-28-3

  • Cat. No. CS-0149187
  • Purity≥95%
  • MDL No.MFCD04115015

*For research and further manufacturing use only, not for direct human use.

4-(4-Fluorophenoxy)piperidine|CS-0149187

Structure of 3413-28-3

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General Information

  • CAS No. 3413-28-3
  • Cat. No. CS-0149187
  • Purity ≥95%
  • MDL No. MFCD04115015
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₄FNO
  • Molecular Weight None
  • Synonym(s) piperidine, 4-(4-fluorophenoxy)-
  • SMILES FC1=CC=C(OC2CCNCC2)C=C1

Description

4-(4-Fluorophenoxy)piperidine features a fluorinated aromatic ring linked to a piperidine core, delivering enhanced metabolic stability and improved membrane permeability. This scaffold integrates readily into bioactive molecules, serving as a key building block in medicinal chemistry for CNS-targeted therapeutics.

Application

4-(4-Fluorophenoxy)piperidine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its fluorinated aryl ether moiety enhances metabolic stability and membrane permeability, while the piperidine core provides a basic nitrogen for salt formation and target engagement. The compound exhibits good bench stability and is compatible with common synthetic workflows, facilitating purification and integration into lead optimization campaigns.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   1.9565
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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