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CS-W001157 4
Total: USD 88.00

4-(2,4-Difluorophenoxy)piperidine

  • CAS No. 367501-08-4

  • Cat. No. CS-0060352
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-(2,4-Difluorophenoxy)piperidine|CS-0060352

Structure of 367501-08-4

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Description

4-(2,4-Difluorophenoxy)piperidine features a fluorinated phenoxy linker that enhances metabolic stability and membrane permeability. This piperidine derivative integrates readily into bioactive scaffolds, serving as a key building block in medicinal chemistry for CNS-targeted compounds.

Application

4-(2,4-Difluorophenoxy)piperidine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard coupling and functionalization reactions. Its piperidine core provides a basic nitrogen for salt formation and hydrogen bonding, while the ortho- and para-fluorinated phenoxy moiety enhances metabolic stability and modulates lipophilicity. The compound exhibits good bench stability and facilitates efficient synthesis of targeted molecules via established amide, Suzuki, or Buchwald-Hartwig protocols.

General Information

  • CAS No. 367501-08-4
  • Cat. No. CS-0060352
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₃F₂NO
  • Molecular Weight 213.22
  • Synonym(s) UKRORGSYN-BB BBV-084314
  • SMILES C1=CC(=C(C=C1F)F)OC2CCNCC2

Computational Chemistry Data

  • TPSA   21.26
  • LogP   2.0956
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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