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Structure of 367501-08-4
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4-(2,4-Difluorophenoxy)piperidine features a fluorinated phenoxy linker that enhances metabolic stability and membrane permeability. This piperidine derivative integrates readily into bioactive scaffolds, serving as a key building block in medicinal chemistry for CNS-targeted compounds.
4-(2,4-Difluorophenoxy)piperidine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard coupling and functionalization reactions. Its piperidine core provides a basic nitrogen for salt formation and hydrogen bonding, while the ortho- and para-fluorinated phenoxy moiety enhances metabolic stability and modulates lipophilicity. The compound exhibits good bench stability and facilitates efficient synthesis of targeted molecules via established amide, Suzuki, or Buchwald-Hartwig protocols.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: