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CS-W001157 4
Total: USD 88.00

5-(4-Chlorophenyl)furan-2-carbaldehyde

  • CAS No. 34035-03-5

  • Cat. No. CS-0042943
  • Purity≥97%
  • MDL No.MFCD00195947

*For research and further manufacturing use only, not for direct human use.

5-(4-Chlorophenyl)furan-2-carbaldehyde|CS-0042943

Structure of 34035-03-5

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General Information

  • CAS No. 34035-03-5
  • Cat. No. CS-0042943
  • Purity ≥97%
  • MDL No. MFCD00195947
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₇ClO₂
  • Molecular Weight 206.63
  • Synonym(s) ART-CHEM-BB B004122
  • SMILES O=CC1=CC=C(C2=CC=C(Cl)C=C2)O1

Description

5-(4-Chlorophenyl)furan-2-carbaldehyde features a furan ring fused with a para-chlorophenyl group and an aldehyde at the 2-position, delivering a rigid, electron-deficient scaffold. This structure enables direct integration into Suzuki-Miyaura couplings and facilitates the synthesis of conjugated heterocycles for materials science applications.

Application

5-(4-Chlorophenyl)furan-2-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient access to heterocyclic scaffolds via aldol condensations and Mannich reactions. Its ortho-aldehyde functionality offers high reactivity in C–C bond formation, while the 4-chlorophenyl group provides excellent functional group tolerance and stability under standard synthetic conditions. The compound facilitates straightforward purification and is well-suited for scale-up in API intermediate synthesis.

Synthesis

  • Route1

    References

    • Murasawa, Shinpei; Sato, Shinichi; Noguchi-Yachide, Tomomi; Hashimoto, Yuichi; Iuchi, Katsuya; Sodeoka, Mikiko; Dodo, Kosuke; Yokomatsu, Tsutomu; Aoyama, Hiroshi Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 21 p. 6384 - 6393,10
  • Route2
    • null|null
      98-01-1
    • In-stock
      1-Chloro-4-iodobenzene|CS-W007395
      637-87-6
    • ~87%
    • In-stock
      5-(4-Chlorophenyl)furan-2-carbaldehyde|CS-0042943
      34035-03-5

    References

    • McClure; Glover; McSorley; Millar; Osterhout; Roschangar Organic letters, 2001 , vol. 3, # 11 p. 1677 - 1680
  • Route3
    • null|null
      98-01-1
    • null|null
      106-47-8
    • ~74%
    • In-stock
      5-(4-Chlorophenyl)furan-2-carbaldehyde|CS-0042943
      34035-03-5

    References

    • Subrahmanya Bhat; Shivarama Holla Heterocyclic Communications, 2003 , vol. 9, # 6 p. 625 - 628

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   30.21
  • LogP   3.4125
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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