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Ethyl 2-chloro-2-ethoxyacetate

  • CAS No. 34006-60-5

  • Cat. No. CS-0663093
  • Molecule weight166.60
  • Purity≥95%
  • MDL No.MFCD00043953

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-chloro-2-ethoxyacetate|CS-0663093

Structure of 34006-60-5

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General Information

  • CAS No. 34006-60-5
  • Cat. No. CS-0663093
  • Purity ≥95%
  • MDL No. MFCD00043953
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁ClO₃
  • Molecular Weight 166.60
  • Synonym(s) None
  • SMILES CCOC(C(=O)OCC)Cl

Description

Ethyl 2-chloro-2-ethoxyacetate is a reactive acylating agent featuring a chloro-substituted alpha-carbon and an ethoxy ester group. This configuration enables selective alkylation in synthetic sequences, particularly in the formation of heterocycles and functionalized intermediates. The molecule exhibits enhanced stability under standard conditions while maintaining high electrophilicity at the carbonyl center.

Application

Ethyl 2-chloro-2-ethoxyacetate serves as a versatile acylating agent and building block in synthetic organic chemistry. Its α-chloro ester functionality enables efficient nucleophilic substitution and Claisen-type condensations, while the ethoxy group enhances solubility and stability. This reagent facilitates the construction of substituted acetate derivatives and heterocyclic scaffolds under mild conditions, offering predictable reactivity and ease of purification—ideal for iterative synthesis workflows in medicinal chemistry and process development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   35.53
  • LogP   1.1509
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   4

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