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CS-W001157 4
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Methyl 2-(2-chloroethoxy)acetate

  • CAS No. 83881-47-4

  • Cat. No. CS-0209481
  • Purity≥97%
  • MDL No.MFCD09030969

*For research and further manufacturing use only, not for direct human use.

Methyl 2-(2-chloroethoxy)acetate|CS-0209481

Structure of 83881-47-4

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General Information

  • CAS No. 83881-47-4
  • Cat. No. CS-0209481
  • Purity ≥97%
  • MDL No. MFCD09030969
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉ClO₃
  • Molecular Weight 152.58
  • Synonym(s) methyl (2-chloroethoxy)acetate; Methyl 2-(2-chloroethoxy)acetate
  • SMILES COC(=O)COCCCl

Description

Methyl 2-(2-chloroethoxy)acetate is a reactive ester featuring a chloroethyl ether handle that enables selective functionalization in synthetic sequences. This moisture-tolerant reagent integrates readily into complex molecular architectures, offering high compatibility with nucleophilic substitution protocols under mild conditions.

Application

Methyl 2-(2-chloroethoxy)acetate serves as a versatile bifunctional building block, enabling efficient synthesis of ether-linked intermediates and heterocyclic systems. The chloroethyl ether moiety facilitates nucleophilic substitution reactions, while the ester group supports transformations such as hydrolysis, reduction, or coupling. Its bench-stable nature and compatibility with standard reaction conditions make it valuable for medicinal chemistry and process development workflows.

Synthesis

  • Route1
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      57253-40-4
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      67-56-1
    • ~%
    • In-stock
      Methyl 2-(2-chloroethoxy)acetate|CS-0209481
      83881-47-4

    References

    • Journal of Organic Chemistry, , vol. 26, p. 4325 - 4327
  • Route2
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      67-56-1
    • In-stock
      2-(2-Chloroethoxy)acetonitrile|CS-0158721
      31250-08-5
    • ~%
    • In-stock
      Methyl 2-(2-chloroethoxy)acetate|CS-0209481
      83881-47-4

    References

    • Suomen Kemistilehti B, , vol. 17, p. 18 Chem.Abstr., , p. 6491
  • Route3
    • null|null
      67-56-1
    • In-stock
      2-(2-Chloroethoxy)acetic acid|CS-W006556
      14869-41-1
    • ~%
    • In-stock
      Methyl 2-(2-chloroethoxy)acetate|CS-0209481
      83881-47-4

    References

    • Journal of Chemical Research, Miniprint, , # 7 p. 1701 - 1720

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2922
Class : 8(6.1)
Packing Group : Ⅲ
Hazard Statements : H301-H312-H316-H318
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.53
  • LogP   0.4148
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   4

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