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CS-W001157 4
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5-Chloro-2,3-dihydro-1H-inden-1-ol

  • CAS No. 33781-38-3

  • Cat. No. CS-W006473
  • Purity≥95%
  • MDL No.MFCD11219500

*For research and further manufacturing use only, not for direct human use.

5-Chloro-2,3-dihydro-1H-inden-1-ol|CS-W006473

Structure of 33781-38-3

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General Information

  • CAS No. 33781-38-3
  • Cat. No. CS-W006473
  • Purity ≥95%
  • MDL No. MFCD11219500
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉ClO
  • Molecular Weight 168.62
  • Synonym(s) 5-chloroindan-1-ol
  • SMILES OC1CCC2=CC(Cl)=CC=C12

Description

5-Chloro-2,3-dihydro-1H-inden-1-ol features a chlorinated indane scaffold with a hydroxyl group at the bridgehead position, offering enhanced polarity and hydrogen-bonding capacity. This bench-stable compound integrates readily into synthetic sequences requiring controlled stereochemistry and serves as a valuable intermediate in medicinal chemistry and materials science applications.

Application

5-Chloro-2,3-dihydro-1H-inden-1-ol serves as a versatile synthetic intermediate for constructing substituted indane scaffolds. Its hydroxyl group enables facile derivatization via esterification, etherification, or oxidation to the corresponding ketone, while the chlorine substituent supports palladium-catalyzed cross-coupling reactions. The molecule exhibits good bench stability and compatibility with standard purification techniques, facilitating integration into multi-step syntheses of pharmaceutical intermediates and functionalized heterocycles.

Synthesis

  • Route1

    References

    • Journal of the American Chemical Society, , vol. 127, # 30 p. 10482 - 10483
  • Route2

    References

    • Bulletin de la Societe Chimique de France, , p. 3096 - 3099
  • Route3
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      108-90-7
    • ~%
    • In-stock
      5-Chloro-2,3-dihydro-1H-inden-1-ol|CS-W006473
      33781-38-3

    References

    • Bulletin de la Societe Chimique de France, , p. 3096 - 3099

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.3196
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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