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CS-W001157 4
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1-Bromo-2-naphthaldehyde

  • CAS No. 3378-82-3

  • Cat. No. CS-W004895
  • Purity≥95%
  • MDL No.MFCD00046368

*For research and further manufacturing use only, not for direct human use.

1-Bromo-2-naphthaldehyde|CS-W004895

Structure of 3378-82-3

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General Information

  • CAS No. 3378-82-3
  • Cat. No. CS-W004895
  • Purity ≥95%
  • MDL No. MFCD00046368
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₇BrO
  • Molecular Weight 235.08
  • Synonym(s) 1-BROMONAPHTHALENE-2-CARBALDEHYDE
  • SMILES O=CC1=CC=C2C=CC=CC2=C1Br

Description

1-Bromo-2-naphthaldehyde features a bromine atom at the 1-position and an aldehyde group at the 2-position of the naphthalene core. This configuration delivers a highly reactive electrophilic site suitable for cross-coupling reactions, particularly in palladium-catalyzed processes. The molecule exhibits enhanced stability under standard handling conditions and serves as a key intermediate in the synthesis of functionalized polycyclic compounds.

Application

1-Bromo-2-naphthaldehyde serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions and nucleophilic substitutions due to its well-defined bromo and aldehyde functionalities. The molecule exhibits bench stability and facilitates efficient synthesis of naphthyl-containing heterocycles, pharmaceutical intermediates, and functionalized aromatic scaffolds with high regiocontrol.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   3.4148
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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