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CS-W001157 4
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Methyl 6-bromo-2-naphthoate

  • CAS No. 33626-98-1

  • Cat. No. CS-W007811
  • Purity≥98%
  • MDL No.MFCD00100408

*For research and further manufacturing use only, not for direct human use.

Methyl 6-bromo-2-naphthoate|CS-W007811

Structure of 33626-98-1

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General Information

  • CAS No. 33626-98-1
  • Cat. No. CS-W007811
  • Purity ≥98%
  • MDL No. MFCD00100408
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₉BrO₂
  • Molecular Weight 265.11
  • Synonym(s) None
  • SMILES O=C(OC)C1=CC=C2C=C(Br)C=CC2=C1

Description

Methyl 6-bromo-2-naphthoate undergoes aromatic Finkelstein reaction followed by hydrolysis to afford 6-iodo-2-naphthoic acid.Methyl 6-bromo-2-naphthoate may be used to synthesize:6-vinyl-2-naphthalencarbaldehydemethyl 6-(3-tert-butyl-4-methoxyphenyl)-2-naphthoatemethyl 6-[3-tert-butyl-4-[(tert-butyldiethylsilyl)oxy]-phenyl]-2-naphthoatemethyl 6-[3-(1-adamantyl)-4-[(tert-butyldimethylsilyl)-oxy]phenyl]-2-naphthoatemethyl 6-[3-(1-adamantyl)-4-[[(2,3-dimethyl-1,3-dioxolan-4-yl)methylloxy]phenyl]-2-naphthoate2-bromo-6-(bromomethyl)naphthalene

Application

Methyl 6-bromo-2-naphthoate serves as a versatile building block in synthetic organic chemistry, enabling bromine-directed functionalization and transition-metal-catalyzed coupling reactions. Its naphthoate scaffold provides enhanced stability and facilitates purification, while the ortho-positioned bromine supports efficient cross-coupling with boronic acids and amines. This reagent functions reliably in palladium-catalyzed transformations, making it well-suited for constructing complex heterocycles and pharmaceutical intermediates under standard bench conditions.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315
Precautionary Statements : P264-P280-P302+P352-P332+P313-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   3.3889
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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