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CS-W001157 4
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6-Amino-2-naphthoic acid

  • CAS No. 116668-47-4

  • Cat. No. CS-0075924
  • Purity≥95%
  • MDL No.MFCD01861831

*For research and further manufacturing use only, not for direct human use.

6-Amino-2-naphthoic acid|CS-0075924

Structure of 116668-47-4

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General Information

  • CAS No. 116668-47-4
  • Cat. No. CS-0075924
  • Purity ≥95%
  • MDL No. MFCD01861831
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₉NO₂
  • Molecular Weight 187.19
  • Synonym(s) 6-Amino-2-naphthalenecarboxylic Acid
  • SMILES O=C(O)C1=CC2=CC=C(N)C=C2C=C1

Description

6-Amino-2-naphthoic acid is a functionalized naphthalene derivative featuring a carboxylic acid group at the 2-position and an amino substituent at the 6-position. This dual functionality enables direct coupling in peptide synthesis and conjugation chemistry, offering enhanced solubility and reactivity compared to unsubstituted analogs. The molecule exhibits strong electron-donating character through the amino group, influencing redox behavior and coordination potential in metal complexes. Its bench-stable nature supports reliable handling under standard laboratory conditions.

Application

6-Amino-2-naphthoic acid serves as a versatile building block in the synthesis of bioactive naphthoic acid derivatives and heterocyclic scaffolds. Its amino and carboxylic acid functionalities enable straightforward derivatization via amide coupling, diazotization, or electrophilic substitution. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for medicinal chemistry campaigns and process development workflows.

Synthesis

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      6-Amino-2-naphthoic acid|CS-0075924
      116668-47-4

    References

    • Journal of the American Pharmaceutical Association (1912-1977), , vol. 41, p. 657
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      6-Amino-2-naphthoic acid|CS-0075924
      116668-47-4

    References

    • Journal of the American Pharmaceutical Association (1912-1977), , vol. 41, p. 657
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      46816-16-4
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    • In-stock
      6-Amino-2-naphthoic acid|CS-0075924
      116668-47-4

    References

    • Chemische Berichte, , vol. 58, p. 1216

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.32
  • LogP   2.1202
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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