Fmoc-R-3-amino-5-hexynic acid

Name: Fmoc-R-3-amino-5-hexynic acid
Brand: ChemScene
Availability: InStock
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CAS No. 332064-94-5
Cat. No. CS-0182727
Purity≥95%
MDL No.MFCD01860910

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Fmoc-R-3-amino-5-hexynic acid|CS-0182727

Structure of 332064-94-5

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Description

Fmoc-R-3-amino-5-hexynic acid features a terminal alkyne group flanked by a protected amine and a robust Fmoc handle, enabling efficient solid-phase peptide synthesis. This orthogonal functionality facilitates site-specific conjugation via copper-catalyzed azide-alkyne cycloaddition, delivering stable triazoles for bioconjugation applications.

Application

Fmoc-R-3-amino-5-hexynic acid serves as a versatile building block for the synthesis of peptidomimetics and bioconjugates, enabling efficient CuAAC click chemistry via its terminal alkyne group. The Fmoc-protected amine facilitates standard solid-phase peptide synthesis, while the carboxylic acid functionality supports direct coupling or derivatization. Its stability under routine bench conditions and compatibility with orthogonal functional groups make it ideal for modular assembly of complex molecular architectures.

General Information

CAS No. 332064-94-5
Cat. No. CS-0182727
Purity ≥95%
MDL No. MFCD01860910
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₁H₁₉NO₄
Molecular Weight 349.38
Synonym(s) Fmoc-(R)-3-Amino-5-hexynoic acid
SMILES C#CC[C@@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)CC(O)=O

Computational Chemistry Data

TPSA 75.63
LogP 3.3917
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Alkyne

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Click Chemistry Reagents Alkyne

Chemical Biology Pharmaceutical Development and Drug Discovery Research Conjugation Chemistry/Click Chemistry Terminal Alkynes

Chemical Biology Conjugation Chemistry/Click Chemistry Terminal Alkynes

Key Words

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Fmoc-R-3-amino-5-hexynic acid

CAS No. 332064-94-5

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