Fmoc-S-3-amino-5-hexynic acid

Name: Fmoc-S-3-amino-5-hexynic acid
Brand: ChemScene
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CAS No. 1217669-02-7
Cat. No. CS-0182726
Molecule weight349.38
Purity≥95%
MDL No.MFCD01861008

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Fmoc-S-3-amino-5-hexynic acid|CS-0182726

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General Information

CAS No. 1217669-02-7
Cat. No. CS-0182726
Purity ≥95%
MDL No. MFCD01861008
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₁H₁₉NO₄
Molecular Weight 349.38
Synonym(s) FMoc-(S)-3-AMino-5-hexynoic acid
SMILES C#CC[C@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)CC(O)=O

Description

Fmoc-S-3-amino-5-hexynic acid integrates a terminal alkyne and primary amine for bioorthogonal conjugation. This bifunctional reagent enables site-specific labeling via CuAAC or strain-promoted reactions, combining high reactivity with stability under standard conditions. The Fmoc group facilitates efficient solid-phase synthesis and protection of the amine.

Application

Fmoc-S-3-amino-5-hexynic acid serves as a versatile building block for the synthesis of peptidomimetics and bioconjugates. Its terminal alkyne enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the Fmoc-protected amine and carboxylic acid facilitate standard solid-phase peptide synthesis. The molecule exhibits excellent bench stability, ease of purification, and compatibility with diverse functional groups, making it ideal for constructing complex scaffolds in medicinal chemistry and chemical biology workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

TPSA 75.63
LogP 3.3917
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Alkyne

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Click Chemistry Reagents Alkyne

Chemical Biology Pharmaceutical Development and Drug Discovery Research Conjugation Chemistry/Click Chemistry Terminal Alkynes

Chemical Biology Conjugation Chemistry/Click Chemistry Terminal Alkynes

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Fmoc-S-3-amino-5-hexynic acid

CAS No. 1217669-02-7

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