8-Bromoquinazoline-2,4-diol

Name: 8-Bromoquinazoline-2,4-diol
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 331646-99-2
Cat. No. CS-0046820
Purity≥95%
MDL No.MFCD11499006

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 331646-99-2

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General Information

CAS No. 331646-99-2
Cat. No. CS-0046820
Purity ≥95%
MDL No. MFCD11499006
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅BrN₂O₂
Molecular Weight 241.04
Synonym(s) 8-bromoquinazoline-2,4(1H,3H)-dione
SMILES OC1=NC(O)=NC2=C(Br)C=CC=C12

Description

8-Bromoquinazoline-2,4-diol features a brominated quinazoline core with two hydroxyl groups at positions 2 and 4, enabling direct functionalization in medicinal chemistry. This electron-deficient scaffold integrates readily into kinase inhibitor libraries and supports efficient derivatization under standard conditions.

Application

8-Bromoquinazoline-2,4-diol serves as a versatile building block for the synthesis of kinase inhibitors and other bioactive heterocycles. Its bromo group enables palladium-catalyzed cross-coupling reactions, while the two hydroxyl functionalities provide sites for derivatization or metal complexation. The compound exhibits good bench stability and facilitates efficient functionalization in standard medicinal chemistry workflows.

Synthesis

Route1
- 124-38-9
- In-stock
  
  114344-60-4
- ~91%
- In-stock
  
  331646-99-2
References
- Hernandez, Armando R.; Kool, Eric T. Organic Letters, 2011 , vol. 13, # 4 p. 676 - 679
Route2
- In-stock
  
  608-30-0
- ~%
- In-stock
  
  331646-99-2
References
- Organic Letters, , vol. 13, # 4 p. 676 - 679

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 66.24
LogP 1.8035
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

Key Words

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8-Bromoquinazoline-2,4-diol

CAS No. 331646-99-2

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