3-Chloro-6-fluoropyridazine

Name: 3-Chloro-6-fluoropyridazine
Brand: ChemScene
Availability: InStock
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CAS No. 33097-38-0
Cat. No. CS-0137004
Purity≥96%
MDL No.MFCD12547767

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 33097-38-0

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General Information

CAS No. 33097-38-0
Cat. No. CS-0137004
Purity ≥96%
MDL No. MFCD12547767
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₂ClFN₂
Molecular Weight None
Synonym(s) Pyridazine,3-chloro-6-fluoro
SMILES FC1=NN=C(Cl)C=C1

Description

3-Chloro-6-fluoropyridazine is a heterocyclic building block featuring complementary halogen substituents that enable selective cross-coupling reactions. The electron-deficient pyridazine core supports efficient transition-metal catalyzed functionalization, while the orthogonal reactivity of chlorine and fluorine allows for sequential derivatization in synthetic sequences. This compound serves as a key scaffold in medicinal chemistry and agrochemical development.

Application

3-Chloro-6-fluoropyridazine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at both the 3- and 6-positions via palladium-catalyzed cross-coupling. Its complementary halogen reactivity facilitates sequential derivatization, while the fluorine substituent enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and is readily purified by standard chromatographic methods, making it well-suited for iterative synthesis of bioactive heterocycles and API intermediates.

Synthesis

Route1
- In-stock
  
  141-30-0
- ~51%
- In-stock
  
  33097-38-0
- In-stock
  
  33097-39-1
References
- Darabantu, Mircea; Lequeux, Thierry; Pommelet, Jean-Claude; Ple, Nelly; Turck, Alain Tetrahedron, 2001 , vol. 57, # 4 p. 739 - 750

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P264-P270-P330

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Computational Chemistry Data

TPSA 25.78
LogP 1.2691
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridazine compounds

Key Words

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3-Chloro-6-fluoropyridazine

CAS No. 33097-38-0

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