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CS-W001157 4
Total: USD 88.00

3,6-Dichloropyridazin

  • CAS No. 141-30-0

  • Cat. No. CS-0015357
  • Purity≥97%
  • MDL No.MFCD00006466

*For research and further manufacturing use only, not for direct human use.

3,6-Dichloropyridazin|CS-0015357

Structure of 141-30-0

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General Information

  • CAS No. 141-30-0
  • Cat. No. CS-0015357
  • Purity ≥97%
  • MDL No. MFCD00006466
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂Cl₂N₂
  • Molecular Weight 148.98
  • Synonym(s) 3,6-Dichlorpyridazin
  • SMILES ClC1=NN=C(Cl)C=C1

Description

3,6-Dichloropyridazine features a rigid heteroaromatic core with two chlorine substituents at electron-deficient positions, enabling selective cross-coupling and nucleophilic substitution reactions. This configuration supports efficient functionalization in medicinal chemistry and agrochemical synthesis, where halogen-directed derivatization enhances target specificity and metabolic stability under standard conditions.

Application

3,6-Dichloropyridazin serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through nucleophilic substitution. Its two orthogonal chlorine sites facilitate sequential functionalization under mild conditions, offering high regiocontrol and excellent stability during storage and handling. Widely used in the synthesis of kinase inhibitors and bioactive nitrogen-containing heterocycles, it functions reliably in standard coupling protocols and demonstrates broad compatibility with diverse functional groups.

Synthesis

  • Route1

    References

    • Journal of Agricultural and Food Chemistry, , vol. 57, # 14 p. 6356 - 6361
  • Route2
    • null|null
      25974-26-9
    • ~94%
    • In-stock
      3,6-Dichloropyridazin|CS-0015357
      141-30-0

    References

    • Chemical and Pharmaceutical Bulletin, , vol. 46, # 10 p. 1656 - 1657
  • Route3
    • 3,6-Pyridazinedione|CS-D0116
      42413-70-7
    • ~88%
    • In-stock
      3,6-Dichloropyridazin|CS-0015357
      141-30-0

    References

    • Journal of Heterocyclic Chemistry, , vol. 36, # 5 p. 1135 - 1142

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.7834
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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