Lot numbers can be found on the outside label of a product:
6-Chloro-3-hydroxypyridazine
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CAS No. 19064-67-6
- Cat. No. CS-W007727
- Purity≥98%
- MDL No.MFCD00233955
*For research and further manufacturing use only, not for direct human use.
Structure of 19064-67-6
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General Information
- CAS No. 19064-67-6
- Cat. No. CS-W007727
- Purity ≥98%
- MDL No. MFCD00233955
- Storage -20°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₄H₃ClN₂O
- Molecular Weight 130.53
- Synonym(s) 6-Chloropyridazin-3-ol
- SMILES ClC1=NN=C(O)C=C1
Description
6-Chloro-3-hydroxypyridazine features a reactive chloro group at the 6-position and a hydroxyl function at the 3-position, enabling direct coupling or derivatization under mild conditions. This dual-functional scaffold integrates readily into heterocyclic libraries, offering enhanced solubility and stability for medicinal chemistry applications.
Application
6-Chloro-3-hydroxypyridazine serves as a versatile building block in medicinal chemistry, enabling direct substitution at the C6 position via nucleophilic displacement. The hydroxyl group at C3 provides a handle for derivatization, including etherification or esterification, while the pyridazine core offers favorable metabolic stability and hydrogen-bonding capacity. Its bench-stable nature and compatibility with standard coupling protocols facilitate efficient synthesis of functionalized heterocycles and API intermediates.
Synthesis
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Route1
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In-stock
141-30-0 - ~95%
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In-stock
19064-67-6
References
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Johnston, Karen A.; Allcock, Robert W.; Jiang, Zhong; Collier, Ian D.; Blakli, Haakon; Rosair, Georgina M.; Bailey, Patrick D.; Morgan, Keith M.; Kohno, Yasushi; Adams, David R. Organic and Biomolecular Chemistry, 2008 , vol. 6, # 1 p. 175 - 186
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References
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Journal of Organic Chemistry, , vol. 24, p. 811
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Route3
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In-stock
17321-20-9 - ~%
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In-stock
19064-67-6
References
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Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 1255 - 1258
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Safety Information
Download SDS|
GHS Pictogram :
N/A
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GHS No : N/A
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Signal Word : N/A
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : N/A
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Precautionary Statements : N/A
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Quality Control
Computational Chemistry Data
- TPSA 45.75
- LogP 0.4233
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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