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CS-W001157 4
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3-Chloro-6-ethoxypyridazine

  • CAS No. 17321-20-9

  • Cat. No. CS-0137007
  • Purity≥98%
  • MDL No.MFCD00270290

*For research and further manufacturing use only, not for direct human use.

3-Chloro-6-ethoxypyridazine|CS-0137007

Structure of 17321-20-9

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General Information

  • CAS No. 17321-20-9
  • Cat. No. CS-0137007
  • Purity ≥98%
  • MDL No. MFCD00270290
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇ClN₂O
  • Molecular Weight 158.59
  • Synonym(s) NSC 94042
  • SMILES CCOC1=NN=C(Cl)C=C1

Description

3-Chloro-6-ethoxypyridazine is a heterocyclic building block featuring a pyridazine core with strategically positioned chloro and ethoxy substituents. This combination imparts enhanced reactivity for cross-coupling and nucleophilic substitution reactions. The molecule exhibits good stability under standard conditions, enabling reliable incorporation into pharmaceutical intermediates and agrochemical scaffolds.

Application

3-Chloro-6-ethoxypyridazine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive chloropyridazine core. The ethoxy group enhances solubility and modulates reactivity, while the molecule exhibits excellent bench stability and compatibility with diverse functional groups. It facilitates efficient synthesis of substituted pyridazines relevant to agrochemical and pharmaceutical scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.01
  • LogP   1.5287
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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