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CS-W001157 4
Total: USD 88.00

3-Chloro-6-methoxypyridazine

  • CAS No. 1722-10-7

  • Cat. No. CS-W001168
  • Purity≥95%
  • MDL No.MFCD00006467

*For research and further manufacturing use only, not for direct human use.

3-Chloro-6-methoxypyridazine|CS-W001168

Structure of 1722-10-7

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General Information

  • CAS No. 1722-10-7
  • Cat. No. CS-W001168
  • Purity ≥95%
  • MDL No. MFCD00006467
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅ClN₂O
  • Molecular Weight 144.56
  • Synonym(s) 3-Methoxy-6-chloropyridazine
  • SMILES COc1ccc(nn1)Cl

Description

3-Chloro-6-methoxypyridazine is a heterocyclic building block featuring a chlorine atom at the 3-position and a methoxy group at the 6-position, enabling selective functionalization in synthetic routes. This electron-deficient pyridazine core facilitates cross-coupling reactions and integrates readily into bioactive scaffolds. The compound exhibits stability under standard bench conditions and offers enhanced solubility in common organic solvents, streamlining handling in process development workflows.

Application

3-Chloro-6-methoxypyridazine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C3 position via palladium-catalyzed cross-coupling reactions. The chloro group exhibits high reactivity in Suzuki, Negishi, and Stille couplings, while the methoxy substituent provides moderate electron-donating character and enhances solubility. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing complex heterocyclic scaffolds in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.01
  • LogP   1.1386
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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