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CS-W001157 4
Total: USD 88.00

3-Chloro-6-iodopyridazine

  • CAS No. 135034-10-5

  • Cat. No. CS-0005642
  • Purity≥96%
  • MDL No.MFCD08275187

*For research and further manufacturing use only, not for direct human use.

3-Chloro-6-iodopyridazine|CS-0005642

Structure of 135034-10-5

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General Information

  • CAS No. 135034-10-5
  • Cat. No. CS-0005642
  • Purity ≥96%
  • MDL No. MFCD08275187
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂ClIN₂
  • Molecular Weight None
  • Synonym(s) Pyridazine, 3-chloro-6-iodo-
  • SMILES IC1=NN=C(Cl)C=C1

Description

3-Chloro-6-iodopyridazine is a halogenated pyridazine derivative featuring complementary reactive sites for cross-coupling transformations. This bifunctional scaffold enables efficient diversification in medicinal chemistry and materials science, combining chlorine and iodine handles for sequential functionalization under mild conditions.

Application

3-Chloro-6-iodopyridazine serves as a versatile bifunctional building block in medicinal chemistry and synthetic organic chemistry. The orthogonal reactivity of the chloro and iodo groups enables sequential cross-coupling reactions, facilitating the construction of complex heterocyclic scaffolds. Its bench-stable nature and compatibility with palladium-catalyzed transformations make it well-suited for modular synthesis workflows in API development and target-oriented synthesis.

Synthesis

  • Route1

    References

    • US2010/4443 A1, ; Page/Page column 34 ;
  • Route2

    References

    • WO2007/22937 A1, ; Page/Page column 26 ; WO 2007/022937 A1
  • Route3
    • 3-Chloropyridazine|CS-0139686
      1120-95-2
    • ~85%
    • In-stock
      3-Chloro-6-iodopyridazine|CS-0005642
      135034-10-5

    References

    • Angewandte Chemie - International Edition, , vol. 50, # 8 p. 1896 - 1900

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.7346
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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