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CS-W001157 4
Total: USD 88.00

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

  • CAS No. 329214-79-1

  • Cat. No. CS-W000912
  • Purity≥96%
  • MDL No.MFCD03084758

*For research and further manufacturing use only, not for direct human use.

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine|CS-W000912

Structure of 329214-79-1

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General Information

  • CAS No. 329214-79-1
  • Cat. No. CS-W000912
  • Purity ≥96%
  • MDL No. MFCD03084758
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₆BNO₂
  • Molecular Weight 205.06
  • Synonym(s) Pyridine-3-boronic acid pinacol ester
  • SMILES CC1(C)OB(OC1(C)C)c1cccnc1

Description

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine features a boronate ester group conjugated to a pyridine ring, enabling efficient Suzuki-Miyaura cross-coupling reactions. The tetramethyl-substituted dioxaborolane enhances stability and solubility under standard conditions. This compound serves as a robust building block for constructing functionalized heteroaryl architectures in medicinal chemistry and materials science.

Application

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine serves as a versatile boronate building block in palladium-catalyzed cross-coupling reactions. Its pyridine moiety provides a robust platform for constructing biaryl and heteroaryl scaffolds, while the tetramethylboronate group ensures excellent stability, ease of handling, and compatibility with a broad range of reaction conditions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   31.35
  • LogP   1.3808
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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