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CS-W001157 4
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2-Methylpyridine-5-boronic acid pinacol ester

  • CAS No. 610768-32-6

  • Cat. No. CS-W000954
  • Purity≥97%
  • MDL No.MFCD08669608

*For research and further manufacturing use only, not for direct human use.

2-Methylpyridine-5-boronic acid pinacol ester|CS-W000954

Structure of 610768-32-6

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General Information

  • CAS No. 610768-32-6
  • Cat. No. CS-W000954
  • Purity ≥97%
  • MDL No. MFCD08669608
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₈BNO₂
  • Molecular Weight 219.09
  • Synonym(s) 6-Methyl-3-pyridylboronic Acid Pinacol Ester
  • SMILES CC1=NC=C(B2OC(C)(C)C(C)(C)O2)C=C1

Description

2-Methylpyridine-5-boronic acid pinacol ester features a pyridyl boronate moiety with a methyl substituent at the ortho position, offering enhanced stability and compatibility in cross-coupling reactions. The pinacol ester protects the boronic acid, enabling reliable handling under ambient conditions while maintaining reactivity in palladium-catalyzed transformations.

Application

2-Methylpyridine-5-boronic acid pinacol ester serves as a stable, bench-ready building block for Suzuki-Miyaura cross-coupling reactions. Its pyridyl boronate functionality enables efficient C–C bond formation with aryl and vinyl halides under mild conditions. The pinacol ester moiety enhances stability and simplifies purification, making it ideal for constructing substituted heterocyclic scaffolds in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   31.35
  • LogP   1.68922
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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