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CS-W001157 4
Total: USD 88.00

4-Methoxybenzohydrazide

  • CAS No. 3290-99-1

  • Cat. No. CS-0116725
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Methoxybenzohydrazide|CS-0116725

Structure of 3290-99-1

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General Information

  • CAS No. 3290-99-1
  • Cat. No. CS-0116725
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀N₂O₂
  • Molecular Weight 166.18
  • Synonym(s) p-Anisoylhydrazine
  • SMILES O=C(NN)C1=CC=C(OC)C=C1

Description

4-Methoxybenzhydrazide may be used to synthesize:N-[(E)-5-bromo-2-hydroxy-3-methoxybenzylidene]-4-methoxybenzohydrazide monohydrate2,5-bis(4-methoxyphenyl)-1,3,4-oxadiazolehydrazone ligands, which readily forms ruthenium(II) hydrazone complexes via reaction with [RuHCl(CO)(PPh3)3]

Application

4-Methoxybenzohydrazide serves as a versatile building block in heterocyclic synthesis, enabling efficient access to hydrazine-based scaffolds through condensation reactions with carbonyl compounds. Its methoxy group enhances solubility and electronic modulation, while the hydrazide functionality offers reliable reactivity in cyclization processes, including formation of benzimidazoles and triazoles. Bench-stable and readily purified by recrystallization, it functions effectively in standard medicinal chemistry workflows.

Synthesis

  • Route1
    • Methyl anisate, ≥99%|CS-1268957
      121-98-2
    • ~94%
    • In-stock
      4-Methoxybenzohydrazide|CS-0116725
      3290-99-1

    References

    • Journal of the American Chemical Society, , vol. 135, # 15 p. 5656 - 5668
  • Route2

    References

    • Journal of Organic Chemistry, , vol. 74, # 16 p. 6410 - 6413
  • Route3
    • p-Anisic acid, ≥99%|CS-1268349
      100-09-4
    • ~89%
    • In-stock
      4-Methoxybenzohydrazide|CS-0116725
      3290-99-1

    References

    • Journal of Chemical Research - Part S, , # 12 p. 768 - 769

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   64.35
  • LogP   0.2987
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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