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tert-Butyl 2-ethyl-4-oxopiperidine-1-carboxylate

  • CAS No. 324769-07-5

  • Cat. No. CS-0130650
  • Molecule weight227.30
  • Purity≥97%
  • MDL No.MFCD07367729

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 2-ethyl-4-oxopiperidine-1-carboxylate|CS-0130650

Structure of 324769-07-5

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General Information

  • CAS No. 324769-07-5
  • Cat. No. CS-0130650
  • Purity ≥97%
  • MDL No. MFCD07367729
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₁NO₃
  • Molecular Weight 227.30
  • Synonym(s) tert-Butyl 2-ethyl-4-oxopiperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-2-ethyl-4-oxopiperidine
  • SMILES O=C1CC(CC)N(C(OC(C)(C)C)=O)CC1

Description

tert-Butyl 2-ethyl-4-oxopiperidine-1-carboxylate is a bench-stable, moisture-tolerant building block featuring a sterically hindered piperidine core with a ketone at the C4 position. This scaffold integrates readily into complex molecular architectures, enabling efficient access to bioactive heterocycles through selective functionalization at the carbonyl and nitrogen sites.

Application

tert-Butyl 2-ethyl-4-oxopiperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to piperidine-based scaffolds. The ketone functionality at C4 supports selective reduction, enolate formation, and nucleophilic addition reactions. The tert-butyl carbamate group provides excellent stability and orthogonal deprotection under mild acidic conditions, facilitating downstream functionalization in multi-step synthesis. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for iterative synthesis of bioactive molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   46.61
  • LogP   2.365
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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