Lot numbers can be found on the outside label of a product:
tert-Butyl 1-(4-bromophenyl)cyclobutylcarbamate
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CAS No. 1032350-06-3
- Cat. No. CS-M1258
- Purity≥95%
- MDL No.MFCD18072661
*For research and further manufacturing use only, not for direct human use.
Structure of 1032350-06-3
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General Information
- CAS No. 1032350-06-3
- Cat. No. CS-M1258
- Purity ≥95%
- MDL No. MFCD18072661
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₅H₂₀BrNO₂
- Molecular Weight 326.23
- Synonym(s) tert-Butyl (1-(4-bromophenyl)cyclobutyl)carbamate
- SMILES O=C(OC(C)(C)C)NC1(CCC1)C(C=C2)=CC=C2Br
Description
tert-Butyl 1-(4-bromophenyl)cyclobutylcarbamate is a bench-stable, moisture-tolerant building block featuring a cyclobutyl scaffold flanked by a brominated phenyl group and a carbamate protecting group. This combination enables direct incorporation into Suzuki-Miyaura coupling reactions and facilitates downstream functionalization in medicinal chemistry campaigns.
Application
tert-Butyl 1-(4-bromophenyl)cyclobutylcarbamate serves as a versatile building block in medicinal chemistry, enabling the introduction of both a brominated aryl handle and a protected amine for subsequent functionalization. The cyclobutylcarbamate moiety provides robust stability under standard reaction conditions, while the tert-butyl group facilitates straightforward deprotection. Its compatibility with palladium-catalyzed cross-coupling reactions and tolerance to diverse functional groups make it well-suited for iterative synthesis of complex scaffolds.
Synthesis
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Route1
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In-stock
24424-99-5 -
1094218-30-0 - ~%
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In-stock
1032350-06-3
References
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT; BÄRFACKER, Lars; SCOTT, William; HÄGEBARTH, Andrea; INCE, Stuart; REHWINKEL, Hartmut; POLITZ, Oliver; NEUHAUS, Roland; BÖMER, Ulf Patent: WO2013/104610 A1, 2013 ; Location in patent: Page/Page column 48 ;
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References
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT; BÄRFACKER, Lars; SCOTT, William; HÄGEBARTH, Andreas; REHWINKEL, Hartmut; POLITZ, Oliver; NEUHAUS, Roland; BÖMER, Ulf Patent: WO2013/104611 A1, 2013 ; Location in patent: Page/Page column 47 ;
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Route3
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In-stock
1193389-40-0 - ~%
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In-stock
1032350-06-3
References
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BAYER PHARMA AKTIENGESELLSCHAFT; INCE, Stuart; REHWINKEL, Hartmut; HAEGEBARTH, Andrea; POLITZ, Oliver; NEUHAUS, Roland; BOeMER, Ulf Patent: WO2012/7416 A1, 2012 ; WO 2012/007416 A1 Title/Abstract Full Text Show Details BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; SCOTT, William; HAeGEBARTH, Andrea; INCE, Stuart; REHWINKEL, Hartmut; POLITZ, Oliver; NEUHAUS, Roland; BRIEM, Hans; BOeMER, Ulf Patent: WO2012/136776 A1, 2012 ; WO 2012/136776 A1
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 38.33
- LogP 4.353
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 2
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Key Words
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