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CS-W001157 4
Total: USD 88.00

(R)-2-(4-Fluorophenyl)-2-hydroxyacetic acid

  • CAS No. 32222-45-0

  • Cat. No. CS-0343264
  • Purity≥98%
  • MDL No.MFCD20638902

*For research and further manufacturing use only, not for direct human use.

(R)-2-(4-Fluorophenyl)-2-hydroxyacetic acid|CS-0343264

Structure of 32222-45-0

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General Information

  • CAS No. 32222-45-0
  • Cat. No. CS-0343264
  • Purity ≥98%
  • MDL No. MFCD20638902
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO₃
  • Molecular Weight 170.14
  • Synonym(s) 4-Fluoro-D-mandelic acid
  • SMILES O[C@H](C1=CC=C(F)C=C1)C(O)=O

Description

This chiral building block features a (R)-configured stereocenter flanked by a hydroxyl group and a 4-fluorophenyl moiety, delivering enhanced metabolic stability. The electron-withdrawing fluorine substituent imparts unique polarity and directional reactivity, enabling selective functionalization in asymmetric synthesis. Bench-stable and moisture-tolerant, it integrates seamlessly into complex molecular architectures for pharmaceutical development.

Application

(R)-2-(4-Fluorophenyl)-2-hydroxyacetic acid serves as a valuable chiral building block in the synthesis of pharmaceutical intermediates, particularly for CNS-targeted agents. Its well-defined stereochemistry and hydroxyl functionality enable reliable derivatization via esterification, amidation, or oxidation. The molecule exhibits good bench stability and facilitates efficient purification, making it suitable for scale-up in medicinal chemistry campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   0.9437
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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