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CS-W001157 4
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5-Chloro-2-hydroxybenzoic acid

  • CAS No. 321-14-2

  • Cat. No. CS-W017582
  • Purity≥98%
  • MDL No.MFCD00002457

*For research and further manufacturing use only, not for direct human use.

5-Chloro-2-hydroxybenzoic acid|CS-W017582

Structure of 321-14-2

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General Information

  • CAS No. 321-14-2
  • Cat. No. CS-W017582
  • Purity ≥98%
  • MDL No. MFCD00002457
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅ClO₃
  • Molecular Weight 172.57
  • Synonym(s) 5-Chlorosalicylic acid; 5-Chloro-2-hydroxybenzoic acid
  • SMILES O=C(O)C1=CC(Cl)=CC=C1O

Description

5-Chloro-2-hydroxybenzoic acid features a chlorine substituent at the meta position relative to the carboxyl group, paired with a phenolic hydroxyl ortho to the acid function. This arrangement imparts enhanced solubility in polar solvents and facilitates participation in intramolecular hydrogen bonding, stabilizing the anionic form under physiological conditions. The molecule serves as a key building block for bioactive heterocycles and functionalized polymers.

Synthesis

  • Route1

    References

    • THE SCRIPPS RESEARCH INSTITUTE; YU, Jin-quan Patent: WO2011/37929 A2, 2011 ; Location in patent: Page/Page column 14; 19-20 ;
  • Route2

    References

    • Docampo Palacios, Maite L.; Pellon Comdom, Rolando F. Synthetic Communications, 2003 , vol. 33, # 10 p. 1783 - 1787
  • Route3

    References

    • Yang, Daoshan; Fu, Hua Chemistry - A European Journal, 2010 , vol. 16, # 8 p. 2366 - 2370

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   1.7438
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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