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CS-W001157 4
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5-Fluoro-2-hydroxybenzoic acid

  • CAS No. 345-16-4

  • Cat. No. CS-W016245
  • Purity≥98%
  • MDL No.MFCD00002456

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-2-hydroxybenzoic acid|CS-W016245

Structure of 345-16-4

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General Information

  • CAS No. 345-16-4
  • Cat. No. CS-W016245
  • Purity ≥98%
  • MDL No. MFCD00002456
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅FO₃
  • Molecular Weight 156.11
  • Synonym(s) 5-Fluorosalicylic acid
  • SMILES O=C(O)C1=CC(F)=CC=C1O

Description

5-Fluorosalicylic acid was used as internal standard in the quantification of salicylic acid.

Application

5-Fluoro-2-hydroxybenzoic acid serves as a versatile building block for bioactive heterocycles and pharmaceutical intermediates. Its ortho-hydroxyl and carboxylic acid groups enable facile derivatization via esterification, amidation, or cyclization reactions. The fluorine substituent enhances metabolic stability and modulates electronic properties, while the compound exhibits good bench stability and compatibility with standard purification techniques.

Synthesis

  • Route1
    • null|null
      368422-23-5
    • ~56%
    • In-stock
      5-Fluoro-2-hydroxybenzoic acid|CS-W016245
      345-16-4

    References

    • Marzi, Elena; Mongin, Florence; Spitaleri, Andrea; Schlosser, Manfred European Journal of Organic Chemistry, 2001 , # 15 p. 2911 - 2915
  • Route2
    • null|null
      1998-90-9
    • ~46%
    • In-stock
      5-Fluoro-2-hydroxybenzoic acid|CS-W016245
      345-16-4

    References

    • Sharma; Ilangovan; Lavanya Synthetic Communications, 2000 , vol. 30, # 3 p. 397 - 405
  • Route3

    References

    • Sharma; Ilangovan; Lavanya Synthetic Communications, 2000 , vol. 30, # 3 p. 397 - 405

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   1.2295
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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