Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

Indolizine-2-carboxylic acid

  • CAS No. 3189-48-8

  • Cat. No. CS-0072759
  • Purity≥97%
  • MDL No.MFCD00266289

*For research and further manufacturing use only, not for direct human use.

Indolizine-2-carboxylic acid|CS-0072759

Structure of 3189-48-8

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 3189-48-8
  • Cat. No. CS-0072759
  • Purity ≥97%
  • MDL No. MFCD00266289
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇NO₂
  • Molecular Weight 161.16
  • Synonym(s) None
  • SMILES O=C(O)C1=CN2C=CC=CC2=C1

Description

Indolizine-2-carboxylic acid features a rigid, electron-deficient heterocyclic core that integrates seamlessly into conjugated systems. This carboxylic acid moiety enables direct functionalization or salt formation, enhancing solubility and reactivity in synthetic transformations. The scaffold serves as a privileged building block for bioactive molecule design and materials chemistry applications.

Application

Indolizine-2-carboxylic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its carboxylic acid functionality enables direct derivatization via amide, ester, or acyl chloride formation, while the fused indolizine core provides structural rigidity and enhanced metabolic stability. The compound exhibits good bench stability and facilitates efficient functionalization under standard coupling conditions, making it well-suited for medicinal chemistry campaigns targeting CNS-active compounds and kinase inhibitors.

Synthesis

  • Route1

    References

    • Bode, Moira L.; Kaye, Perry T.; George, Rosemary Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 20 p. 3023 - 3028
  • Route2
    • null|null
      4491-43-4
    • ~%
    • In-stock
      Indolizine-2-carboxylic acid|CS-0072759
      3189-48-8

    References

    • Wiley; Knabeschuh Journal of Organic Chemistry, 1953 , vol. 18, p. 836,839 Full Text Show Details Diels; Alder Justus Liebigs Annalen der Chemie, 1932 , vol. 498, p. 16,26, 46 Justus Liebigs Annalen der Chemie, 1933 , vol. 505, p. 103,110, 132
  • Route3
    • null|null
      109-06-8
    • null|null
      70-23-5
    • ~%
    • In-stock
      Indolizine-2-carboxylic acid|CS-0072759
      3189-48-8

    References

    • Borrows; Holland Journal of the Chemical Society, 1947 , p. 670

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   41.71
  • LogP   1.6375
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • Indolizine-2-carboxylic acid sigmaIndolizine-2-carboxylic acid manufacturerIndolizine-2-carboxylic acid priceIndolizine-2-carboxylic acid structureIndolizine-2-carboxylic acid SDSbuy Indolizine-2-carboxylic acidIndolizine-2-carboxylic acid supplierIndolizine-2-carboxylic acid usesIndolizine-2-carboxylic acid molecular weightprice of Indolizine-2-carboxylic acidIndolizine-2-carboxylic acid chemical name formula of Indolizine-2-carboxylic acid
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label