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Methyl indolizine-2-carboxylate

  • CAS No. 16959-62-9

  • Cat. No. CS-0067843
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl indolizine-2-carboxylate|CS-0067843

Structure of 16959-62-9

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General Information

  • CAS No. 16959-62-9
  • Cat. No. CS-0067843
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉NO₂
  • Molecular Weight 175.18
  • Synonym(s) Indolizine-2-carboxylic acid methyl ester
  • SMILES O=C(C1=CN2C=CC=CC2=C1)OC

Description

Methyl indolizine-2-carboxylate is a bench-stable heterocyclic ester featuring a fused bicyclic core with a carboxylate handle at the 2-position. This scaffold integrates readily into synthetic sequences requiring electron-rich, planar building blocks. The methyl ester group enables straightforward derivatization, while the indolizine framework provides rigidity and enhanced solubility in common organic solvents.

Application

Methyl indolizine-2-carboxylate serves as a versatile heterocyclic building block for the synthesis of indolizine-based scaffolds. Its carboxylate functionality enables facile derivatization via ester reduction, amidation, or cross-coupling reactions. The molecule exhibits good bench stability and compatibility with standard reaction conditions, facilitating efficient access to medicinally relevant frameworks in medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   30.71
  • LogP   1.7259
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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