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CS-W001157 4
Total: USD 88.00

5H-Cyclopenta[b]pyridin-7(6H)-one

  • CAS No. 31170-78-2

  • Cat. No. CS-W003423
  • Purity≥95%
  • MDL No.MFCD07778341

*For research and further manufacturing use only, not for direct human use.

5H-Cyclopenta[b]pyridin-7(6H)-one|CS-W003423

Structure of 31170-78-2

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General Information

  • CAS No. 31170-78-2
  • Cat. No. CS-W003423
  • Purity ≥95%
  • MDL No. MFCD07778341
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇NO
  • Molecular Weight 133.15
  • Synonym(s) 7H-Cyclopenta[b]pyridin-7-one,5,6-dihydro-
  • SMILES O=C1CCc2c1nccc2

Description

5H-Cyclopenta[b]pyridin-7(6H)-one is a fused heterocyclic scaffold featuring a bicyclic core with a lactam functionality. This rigid, electron-deficient system integrates readily into bioactive molecule design, offering enhanced metabolic stability and predictable conformational behavior in medicinal chemistry applications.

Application

5H-Cyclopenta[b]pyridin-7(6H)-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to fused polycyclic scaffolds. Its stable enolizable carbonyl and aromatic core facilitate electrophilic substitution, transition-metal-catalyzed coupling, and functionalization at C5 and C6 positions. The compound exhibits excellent bench stability and compatibility with common protecting groups, supporting straightforward purification and integration into multi-step synthesis workflows.

Synthesis

  • Route1
    • null|null
      74701-35-2
    • ~76%
    • In-stock
      5H-Cyclopenta[b]pyridin-7(6H)-one|CS-W003423
      31170-78-2

    References

    • Allergan, Inc. Patent: US2008/255239 A1, 2008 ; Location in patent: Page/Page column 32 ; US 20080255239 A1
  • Route2

    References

    • Andreotti, Daniele; Miserazzi, Emanuele; Nalin, Arnaldo; Pozzan, Alfonso; Profeta, Roberto; Spada, Simone Tetrahedron Letters, 2010 , vol. 51, # 50 p. 6526 - 6530
  • Route3

    References

    • Journal of Organic Chemistry, , vol. 49, # 12 p. 2208 - 2212

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.2105
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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