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2-Chloro-5,6-dihydro-7H-cyclopenta[b]pyridin-7-one

  • CAS No. 1150617-92-7

  • Cat. No. CS-0308842
  • Purity≥98%
  • MDL No.MFCD12024557

*For research and further manufacturing use only, not for direct human use.

2-Chloro-5,6-dihydro-7H-cyclopenta[b]pyridin-7-one|CS-0308842

Structure of 1150617-92-7

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General Information

  • CAS No. 1150617-92-7
  • Cat. No. CS-0308842
  • Purity ≥98%
  • MDL No. MFCD12024557
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆ClNO
  • Molecular Weight 167.59
  • Synonym(s) 2-Chloro-5,6-dihydrocyclopenta[b]pyridin-7-one
  • SMILES C1CC(=O)C2=C1C=CC(=N2)Cl

Description

2-Chloro-5,6-dihydro-7H-cyclopenta[b]pyridin-7-one is a heterocyclic scaffold featuring a chlorine substituent at the 2-position and a ketone functionality at C7. This electron-deficient core integrates readily into medicinal chemistry campaigns, offering a rigid, planar framework for probing target engagement in kinase and GPCR modulators.

Application

2-Chloro-5,6-dihydro-7H-cyclopenta[b]pyridin-7-one serves as a versatile building block for heterocyclic synthesis, enabling efficient access to substituted pyridine and fused ring systems. Its electrophilic chlorine at the C2 position facilitates nucleophilic substitution under mild conditions, while the enone functionality supports conjugate addition and cyclization reactions. The scaffold exhibits good bench stability and compatibility with common protecting groups, making it suitable for iterative synthetic sequences in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.8639
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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