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CS-W001157 4
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tert-​Butyl (2R,​5S)​-​2,​5-​dimethylpiperazine-​1-​carboxylate

  • CAS No. 309915-46-6

  • Cat. No. CS-B0967
  • Purity≥98%
  • MDL No.MFCD06797728

*For research and further manufacturing use only, not for direct human use.

tert-​Butyl (2R,​5S)​-​2,​5-​dimethylpiperazine-​1-​carboxylate|CS-B0967

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General Information

  • CAS No. 309915-46-6
  • Cat. No. CS-B0967
  • Purity ≥98%
  • MDL No. MFCD06797728
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₂N₂O₂
  • Molecular Weight None
  • Synonym(s) TERT-BUTYL(2R,5S)-2,5-DIMETHYLPIPERAZINE-1-CARBOXYLATE
  • SMILES O=C(N1[C@H](C)CN[C@@H](C)C1)OC(C)(C)C

Description

tert-Butyl (2R,5S)-2,5-dimethylpiperazine-1-carboxylate features a stereochemically defined piperazine core with two methyl substituents at the 2- and 5-positions, delivering enhanced conformational rigidity. The tert-butyl ester group provides excellent stability and ease of handling under standard conditions, enabling straightforward deprotection to yield the parent amine for downstream applications in medicinal chemistry and catalyst design.

Application

tert-Butyl (2R,5S)-2,5-dimethylpiperazine-1-carboxylate serves as a stereochemically defined piperazine building block, enabling the efficient construction of complex heterocyclic scaffolds in medicinal chemistry. Its tert-butyl carbamate group offers excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. The defined (2R,5S) stereochemistry ensures predictable conformational behavior in downstream applications, while the dimethyl substitution enhances metabolic stability and modulates solubility in synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   1.6037
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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