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Structure of 2815-34-1
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trans-2,5-Dimethylpiperazine is a bench-stable, sterically hindered piperazine derivative featuring two methyl groups at the 2 and 5 positions in a trans configuration. This structural arrangement enhances its solubility in organic media while maintaining strong nitrogen basicity, enabling efficient coupling in amine-functionalization reactions. The molecule integrates readily into complex scaffolds during medicinal chemistry optimization.
trans-2,5-Dimethylpiperazine serves as a versatile nitrogen-containing heterocycle in medicinal chemistry, offering enhanced metabolic stability and defined stereochemistry. Its rigid trans configuration facilitates predictable conformational behavior in ligand design, while the tertiary amine centers enable salt formation and hydrogen bonding interactions. The molecule exhibits good bench stability, moderate basicity, and compatibility with standard coupling and functionalization protocols, making it a reliable scaffold for building complex molecular architectures in API development.
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GHS Pictogram :
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GHS No : GHS02,GHS06
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Signal Word : Danger
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UN#: 2926
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Class : 4.1 (6.1)
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Packing Group : Ⅱ
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Hazard Statements : H228-H311
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Precautionary Statements : P210-P240-P241-P280-P302+P352-P361-P363-P370+P378-P405-P501
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Lot numbers can be found on the outside label of a product: