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CS-W001157 4
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tert-Butyl 4-(4-aminobenzyl)piperazine-1-carboxylate

  • CAS No. 304897-49-2

  • Cat. No. CS-W019936
  • Purity≥97%
  • MDL No.MFCD06797795

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(4-aminobenzyl)piperazine-1-carboxylate|CS-W019936

Structure of 304897-49-2

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General Information

  • CAS No. 304897-49-2
  • Cat. No. CS-W019936
  • Purity ≥97%
  • MDL No. MFCD06797795
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₅N₃O₂
  • Molecular Weight 291.39
  • Synonym(s) 4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester
  • SMILES O=C(N1CCN(CC2=CC=C(N)C=C2)CC1)OC(C)(C)C

Description

tert-Butyl 4-(4-aminobenzyl)piperazine-1-carboxylate features a piperazine core functionalized with a para-aminobenzyl group and a tert-butyl ester, enabling straightforward deprotection to yield the free amine. This bench-stable intermediate integrates readily into bioconjugation and medicinal chemistry campaigns requiring flexible, electron-rich linkers for targeted compound assembly.

Application

tert-Butyl 4-(4-aminobenzyl)piperazine-1-carboxylate serves as a versatile building block for medicinal chemistry, enabling efficient access to piperazine-based scaffolds. The protected amine and benzyl functionality offer orthogonal reactivity, facilitating downstream modifications via amidation, alkylation, or reduction. Its bench-stable tert-butyl carbamate group simplifies purification and enables selective deprotection under mild acidic conditions, making it well-suited for iterative synthesis in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   58.8
  • LogP   2.3215
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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