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4,6-Dichloro-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one

  • CAS No. 1201676-03-0

  • Cat. No. CS-0157293
  • Purity≥95%
  • MDL No.MFCD16658728

*For research and further manufacturing use only, not for direct human use.

4,6-Dichloro-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one|CS-0157293

Structure of 1201676-03-0

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General Information

  • CAS No. 1201676-03-0
  • Cat. No. CS-0157293
  • Purity ≥95%
  • MDL No. MFCD16658728
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄Cl₂N₂O
  • Molecular Weight 203.03
  • Synonym(s) 4,6-DICHLORO-2,3-DIHYDROPYRROLO[3,4-C]PYRIDIN-1-ONE
  • SMILES C1=C2C(=C(Cl)N=C1Cl)CNC2=O

Description

4,6-Dichloro-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one is a bench-stable heterocyclic scaffold featuring two chlorine substituents at electron-deficient positions. This configuration enhances its reactivity in cross-coupling and electrophilic substitution processes. The compound serves as a key intermediate in the synthesis of bioactive molecules, particularly within kinase inhibitor and medicinal chemistry research.

Application

4,6-Dichloro-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one serves as a versatile building block for heterocyclic synthesis, enabling efficient access to substituted pyrrolopyridine scaffolds. The dichloro substitution pattern facilitates directed metalation and subsequent functionalization, while the dihydro-1H-pyrrolo[3,4-c]pyridin-1-one core exhibits bench stability and compatibility with standard coupling reactions. Its defined regiochemistry supports predictable transformations in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   41.99
  • LogP   1.6318
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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