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CS-W001157 4
Total: USD 88.00

(2-Chloro-5-methoxypyridin-4-yl)boronic acid

  • CAS No. 1072945-98-2

  • Cat. No. CS-0141801
  • Purity≥97%
  • MDL No.MFCD09972106

*For research and further manufacturing use only, not for direct human use.

(2-Chloro-5-methoxypyridin-4-yl)boronic acid|CS-0141801

Structure of 1072945-98-2

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General Information

  • CAS No. 1072945-98-2
  • Cat. No. CS-0141801
  • Purity ≥97%
  • MDL No. MFCD09972106
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇BClNO₃
  • Molecular Weight 187.39
  • Synonym(s) 2-Chloro-5-methoxypyridine-4-boronic acid
  • SMILES OB(C1=CC(Cl)=NC=C1OC)O

Description

This boronate moiety integrates readily into Suzuki-Miyaura cross-coupling reactions under standard conditions, delivering functionalized pyridine derivatives with high efficiency. The para-chloro and methoxy substituents provide orthogonal reactivity and enhanced solubility, enabling streamlined synthesis of complex heterocyclic scaffolds.

Application

(2-Chloro-5-methoxypyridin-4-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl architectures. The chloropyridine moiety offers orthogonal reactivity for downstream functionalization, while the boronic acid group provides excellent bench stability and compatibility with diverse reaction conditions. Its methoxy substituent enhances solubility and modulates electronic properties, making it well-suited for medicinal chemistry applications and scale-up processes.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

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Computational Chemistry Data

  • TPSA   62.58
  • LogP   -0.5766
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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