Lot numbers can be found on the outside label of a product:
tert-Butyl (4-formylpyridin-2-yl)carbamate
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CAS No. 304873-65-2
- Cat. No. CS-W018810
- Purity≥95%
- MDL No.MFCD09757496
*For research and further manufacturing use only, not for direct human use.
Structure of 304873-65-2
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General Information
- CAS No. 304873-65-2
- Cat. No. CS-W018810
- Purity ≥95%
- MDL No. MFCD09757496
- Storage 4°C, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₁₄N₂O₃
- Molecular Weight 222.24
- Synonym(s) 2-Boc-amino-4-formylpyridine
- SMILES O=C(OC(C)(C)C)NC1=NC=CC(C=O)=C1
Description
tert-Butyl (4-formylpyridin-2-yl)carbamate features a pyridine ring bearing both a formyl group at the 4-position and a carbamate-protected amine at the 2-position. This bifunctional scaffold enables direct incorporation into late-stage diversification strategies, offering a stable, moisture-tolerant platform for constructing bioactive heterocycles via reductive amination or nucleophilic addition reactions.
Application
tert-Butyl (4-formylpyridin-2-yl)carbamate serves as a versatile building block for pyridine-based scaffolds, enabling direct functionalization at the 4-position via formyl group transformations. Its stability under standard reaction conditions and compatibility with common coupling protocols facilitate efficient access to substituted heterocycles. The carbamate protecting group allows for selective deprotection and further derivatization, supporting applications in medicinal chemistry and process development.
Synthesis
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Route1
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In-stock
304873-62-9 - ~85%
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In-stock
304873-65-2
References
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SCHERING CORPORATION Patent: WO2008/108958 A2, 2008 ; Location in patent: Page/Page column 32 ;
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Route2
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In-stock
6937-03-7 - ~%
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In-stock
304873-65-2
References
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Poon, Jia-Fei; Alao, John Patrick; Sunnerhagen, Per; Diner, Peter Organic and Biomolecular Chemistry, 2013 , vol. 11, # 27 p. 4526 - 4536
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Route3
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639091-75-1 - ~%
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In-stock
304873-65-2
References
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Poon, Jia-Fei; Alao, John Patrick; Sunnerhagen, Per; Diner, Peter Organic and Biomolecular Chemistry, 2013 , vol. 11, # 27 p. 4526 - 4536
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 68.29
- LogP 2.2411
- H_Acceptors 4
- H_Donors 1
- Rotatable_Bonds 2
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Key Words
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