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CS-W001157 4
Total: USD 88.00

2-(Trifluoromethyl)benzylamine

  • CAS No. 3048-01-9

  • Cat. No. CS-0030560
  • Purity≥95%
  • MDL No.MFCD00010297

*For research and further manufacturing use only, not for direct human use.

2-(Trifluoromethyl)benzylamine|CS-0030560

Structure of 3048-01-9

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General Information

  • CAS No. 3048-01-9
  • Cat. No. CS-0030560
  • Purity ≥95%
  • MDL No. MFCD00010297
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈F₃N
  • Molecular Weight None
  • Synonym(s) 2-Trifluoromethylbenzylamine
  • SMILES NCC1=CC=CC=C1C(F)(F)F

Description

2-(Trifluoromethyl)benzylamine features a trifluoromethyl group that imparts strong electron-withdrawing character and enhanced metabolic stability. This arylalkyl amine integrates readily into bioactive scaffolds, offering improved membrane permeability and resistance to oxidative degradation in medicinal chemistry applications.

Application

2-(Trifluoromethyl)benzylamine serves as a valuable building block in medicinal chemistry, enabling the synthesis of bioactive compounds through amine coupling and functionalization reactions. Its trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the benzylamine handle facilitates straightforward derivatization. The compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthetic workflows in API development.

Synthesis

  • Route1

    References

    • Takamizawa; Wakasa; Fuchikami Synlett, 2001 , # 10 p. 1623 - 1625
  • Route2
    • null|null
      823189-03-3
    • ~%
    • In-stock
      2-(Trifluoromethyl)benzylamine|CS-0030560
      3048-01-9

    References

    • US2012/108583 A1, ; Page/Page column 23 ; US 20120108583 A1
  • Route3
    • In-stock
      2-(Trifluoromethyl)benzamide|CS-W015962
      360-64-5
    • ~68%
    • In-stock
      2-(Trifluoromethyl)benzylamine|CS-0030560
      3048-01-9
    • null|null
      1280540-91-1

    References

    • Tetrahedron Letters, , vol. 52, # 32 p. 4072 - 4075

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P310-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.1641
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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