1-(pyrimidin-2-yl)piperidine-4-carboxylic acid

Name: 1-(pyrimidin-2-yl)piperidine-4-carboxylic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 303144-44-7
Cat. No. CS-0199393
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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1-(pyrimidin-2-yl)piperidine-4-carboxylic acid|CS-0199393

Structure of 303144-44-7

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General Information

CAS No. 303144-44-7
Cat. No. CS-0199393
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₃N₃O₂
Molecular Weight 207.23
Synonym(s) T6N CNJ B- AT6NTJ DVQ
SMILES C1=CN=C(N=C1)N2CCC(CC2)C(=O)O

Description

1-(pyrimidin-2-yl)piperidine-4-carboxylic acid features a pyrimidine ring linked to a piperidine scaffold bearing a carboxylic acid at the 4-position, enabling integration into bioactive molecules. This structure combines hydrogen-bonding capacity with moderate lipophilicity, facilitating interactions in target binding sites. The compound exhibits bench-stable handling characteristics and serves as a key intermediate in medicinal chemistry for kinase inhibitors and CNS-targeted therapeutics.

Application

1-(Pyrimidin-2-yl)piperidine-4-carboxylic acid serves as a versatile building block for medicinal chemistry campaigns, enabling the construction of bioactive heterocyclic scaffolds. Its amide and carboxylic acid functionalities offer orthogonal reactivity for peptide coupling and derivatization, while the pyrimidine ring provides a robust hydrogen-bonding motif. The molecule exhibits excellent bench stability and facilitates purification via standard chromatographic methods, making it well-suited for high-throughput synthesis and lead optimization workflows.

Synthesis

Route1
- 111247-60-0
- ~86%
- In-stock
  
  303144-44-7
References
- VANTIA LIMITED; BATT, Andrzej, Roman; HEENEY, Celine, Marguerite, Simone Patent: WO2010/97576 A1, 2010 ; Location in patent: Page/Page column 43-44 ; WO 2010/097576 A1
Route2
- In-stock
  
  1126-09-6
- ~%
- In-stock
  
  303144-44-7
References
- Journal of Medicinal Chemistry, , vol. 56, # 21 p. 8696 - 8711

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 66.32
LogP 0.7776
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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1-(pyrimidin-2-yl)piperidine-4-carboxylic acid

CAS No. 303144-44-7

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