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6-Chloropyridazine-3-carbaldehyde

  • CAS No. 303085-53-2

  • Cat. No. CS-0019042
  • Purity≥95%
  • MDL No.MFCD10698041

*For research and further manufacturing use only, not for direct human use.

6-Chloropyridazine-3-carbaldehyde|CS-0019042

Structure of 303085-53-2

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General Information

  • CAS No. 303085-53-2
  • Cat. No. CS-0019042
  • Purity ≥95%
  • MDL No. MFCD10698041
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClN₂O
  • Molecular Weight 142.54
  • Synonym(s) 6-Chloropyridazine-3-carboxaldehyde
  • SMILES O=CC1=NN=C(Cl)C=C1

Description

6-Chloropyridazine-3-carbaldehyde features a chlorinated pyridazine core paired with an aldehyde functional group, enabling direct coupling in synthetic transformations. The electron-deficient heterocycle facilitates nucleophilic addition and conjugate reactions, while the aldehyde offers site-specific derivatization under mild conditions. This compound serves as a key building block for bioactive molecule synthesis.

Application

6-Chloropyridazine-3-carbaldehyde serves as a versatile building block for the synthesis of pyridazinyl heterocycles, enabling efficient coupling reactions and functional group interconversions. Its electrophilic aldehyde and chloro substituents offer orthogonal reactivity, facilitating late-stage derivatization in medicinal chemistry. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for scalable synthetic workflows.

Synthesis

  • Route1

    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2004/56817 A1, 2004 ; Location in patent: Page 91-92 ; WO 2004/056817 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   42.85
  • LogP   0.9425
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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