2-Chloro-5-hydrazinylpyrazine

Name: 2-Chloro-5-hydrazinylpyrazine
Brand: ChemScene
Availability: InStock
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CAS No. 299441-13-7
Cat. No. CS-0054769
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-5-hydrazinylpyrazine|CS-0054769

Structure of 299441-13-7

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Description

2-Chloro-5-hydrazinylpyrazine features a reactive hydrazino group positioned ortho to a chlorine atom on a pyrazine core, enabling selective coupling reactions. This electron-deficient heterocycle facilitates nucleophilic substitution under mild conditions, offering a robust scaffold for constructing bioactive molecules in medicinal chemistry and agrochemical development.

Application

2-Chloro-5-hydrazinylpyrazine serves as a versatile building block for the construction of pyrazine-based heterocycles and bioactive scaffolds. The hydrazinyl group enables facile cyclization with carbonyl derivatives, while the chloropyrazine moiety supports palladium-catalyzed cross-coupling reactions. Its stability under standard bench conditions and compatibility with diverse functional groups facilitate efficient synthesis of pharmaceutical intermediates and agrochemical candidates.

General Information

CAS No. 299441-13-7
Cat. No. CS-0054769
Purity ≥97%
MDL No. None
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₅ClN₄
Molecular Weight 144.56
Synonym(s) Pyrazine,2-chloro-5-hydrazinyl-
SMILES NNC1=NC=C(Cl)N=C1

Computational Chemistry Data

TPSA 63.83
LogP 0.4156
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302+H312+H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazine compounds

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2-Chloro-5-hydrazinylpyrazine

CAS No. 299441-13-7

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