2-Chloro-3-hydrazinylpyrazine

Name: 2-Chloro-3-hydrazinylpyrazine
Brand: ChemScene
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CAS No. 63286-28-2
Cat. No. CS-W011003
Purity≥95%
MDL No.MFCD08272804

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-3-hydrazinylpyrazine|CS-W011003

Structure of 63286-28-2

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Description

2-Chloro-3-hydrazinylpyrazine features a reactive hydrazino group positioned ortho to a chlorine-bearing pyrazine ring, enabling selective coupling in heterocyclic scaffold elaboration. This electron-deficient system facilitates nucleophilic substitution under mild conditions, offering a robust handle for constructing bioactive nitrogen-rich architectures in medicinal chemistry and materials science applications.

Application

2-Chloro-3-hydrazinylpyrazine serves as a versatile building block in heterocyclic synthesis, enabling efficient access to pyrazine-based scaffolds through nucleophilic substitution and cyclization reactions. The hydrazinyl group facilitates condensation with carbonyl partners, while the chloro substituent offers orthogonal reactivity for further functionalization. Its bench-stable nature and compatibility with common reaction conditions make it well-suited for medicinal chemistry and process development workflows.

General Information

CAS No. 63286-28-2
Cat. No. CS-W011003
Purity ≥95%
MDL No. MFCD08272804
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₅ClN₄
Molecular Weight 144.56
Synonym(s) 3-Chloro-2(H)-pyrazinone hydrazone
SMILES NNC1=NC=CN=C1Cl

Computational Chemistry Data

TPSA 63.83
LogP 0.4156
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS05,GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazine compounds

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2-Chloro-3-hydrazinylpyrazine

CAS No. 63286-28-2

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