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CS-W001157 4
Total: USD 88.00

3,3-Difluoropropanoic acid

  • CAS No. 155142-69-1

  • Cat. No. CS-0054587
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3,3-Difluoropropanoic acid|CS-0054587

Structure of 155142-69-1

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General Information

  • CAS No. 155142-69-1
  • Cat. No. CS-0054587
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₄F₂O₂
  • Molecular Weight 110.06
  • Synonym(s) 3,3-Difluoropropionic acid
  • SMILES OC(=O)CC(F)F

Description

3,3-Difluoropropanoic acid features a highly polarized carbonyl group flanked by two fluorine atoms, imparting enhanced electrophilicity and metabolic stability. This electron-deficient acyl moiety integrates readily into bioactive scaffolds, enabling efficient derivatization under mild conditions. The molecule exhibits improved lipophilicity and resistance to enzymatic degradation compared to non-fluorinated analogs, making it valuable for medicinal chemistry campaigns targeting membrane-permeable compounds.

Application

3,3-Difluoropropanoic acid serves as a valuable building block in medicinal chemistry, enabling the introduction of metabolically stable trifluoromethyl-like motifs. Its fluorinated alkyl chain enhances lipophilicity and bioavailability while improving resistance to oxidative metabolism. The carboxylic acid functionality facilitates direct derivatization into esters, amides, or acyl chlorides, supporting diverse downstream transformations. Bench-stable and compatible with standard purification protocols, it functions reliably in peptide coupling, heterocycle synthesis, and macrocyclic scaffold construction.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   0.7262
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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