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Fmoc-N-amido-PEG2-alcohol

  • CAS No. 299430-87-8

  • Cat. No. CS-0147734
  • Purity≥98%
  • MDL No.MFCD04974286

*For research and further manufacturing use only, not for direct human use.

Fmoc-N-amido-PEG2-alcohol|CS-0147734

Structure of 299430-87-8

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General Information

  • CAS No. 299430-87-8
  • Cat. No. CS-0147734
  • Purity ≥98%
  • MDL No. MFCD04974286
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₂₁NO₄
  • Molecular Weight 327.37
  • Synonym(s) None
  • SMILES OCCOCCNC(OCC1C(C=CC=C2)=C2C3=C1C=CC=C3)=O

Description

Fmoc-N-amido-PEG2-alcohol features a stable amide linkage between the Fmoc group and PEG2 spacer, terminating in a primary alcohol. This structure enables reliable conjugation in peptide synthesis and bioconjugation workflows, offering enhanced solubility and controlled chain length for modular molecular design.

Application

Fmoc-N-amido-PEG2-alcohol serves as a versatile bifunctional linker for peptide and oligonucleotide synthesis, enabling efficient conjugation via its terminal hydroxyl group while the Fmoc moiety provides orthogonal protection for amine-directed coupling. The PEG2 spacer enhances solubility and reduces aggregation in solid-phase workflows. Its bench-stable nature and compatibility with standard deprotection protocols make it ideal for building complex biomolecular architectures.

Synthesis

  • Route1
    • null|null
      28920-43-6
    • null|null
      929-06-6
    • ~96%
    • In-stock
      Fmoc-N-amido-PEG2-alcohol|CS-0147734
      299430-87-8

    References

    • Nasopoulou, Magdalini; Georgiadis, Dimitris; Matziari, Magdalini; Dive, Vincent; Yiotakis, Athanasios Journal of Organic Chemistry, 2007 , vol. 72, # 19 p. 7222 - 7228

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   67.79
  • LogP   2.534
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   7

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