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CS-W001157 4
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PEG2-MeN-Boc

  • CAS No. 1628679-52-6

  • Cat. No. CS-0370537
  • Purity≥97%
  • MDL No.MFCD31557927

*For research and further manufacturing use only, not for direct human use.

PEG2-MeN-Boc|CS-0370537

Structure of 1628679-52-6

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General Information

  • CAS No. 1628679-52-6
  • Cat. No. CS-0370537
  • Purity ≥97%
  • MDL No. MFCD31557927
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₁NO₄
  • Molecular Weight 219.28
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N(C)CCOCCO

Description

tert-Butyl (2-(2-hydroxyethoxy)ethyl)(methyl)carbamate is a bench-stable, moisture-tolerant protecting group reagent designed for selective amine derivatization. This carbamate features a hydrophilic ethylene glycol tether that enhances solubility in polar solvents while maintaining compatibility with standard deprotection protocols. The tert-butyl moiety provides robust protection under mild acidic conditions, enabling efficient release of primary amines without side reactions. Its modular structure supports integration into peptide synthesis and bioconjugation workflows, offering high chemoselectivity and predictable cleavage behavior.

Application

tert-Butyl (2-(2-hydroxyethoxy)ethyl)(methyl)carbamate serves as a versatile bifunctional protecting group reagent, enabling selective protection of primary amines while retaining a pendant hydroxyl for further derivatization. Its tert-butyl carbamate moiety offers robust stability under basic conditions and mild deprotection with trifluoroacetic acid, while the hydroxyethyl side chain facilitates conjugation or orthogonal functionalization in peptide and nucleoside synthesis. The molecule exhibits excellent bench stability, ease of purification, and compatibility with standard coupling protocols.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   59
  • LogP   0.8622
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   5

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