Fmoc-Gly-OH

Name: Fmoc-Gly-OH
Brand: ChemScene
Availability: InStock
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CAS No. 29022-11-5
Cat. No. CS-D1477
Purity≥97%
MDL No.MFCD00037140

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 29022-11-5

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General Information

CAS No. 29022-11-5
Cat. No. CS-D1477
Purity ≥97%
MDL No. MFCD00037140
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₇H₁₅NO₄
Molecular Weight 297.31
Synonym(s) Fmoc-glycine
SMILES O=C(O)CNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Description

Fmoc-Gly-OH is a bench-stable, moisture-tolerant amino acid derivative featuring a fluorenylmethoxy carbonyl (Fmoc) protecting group on the α-amino function. This derivative facilitates efficient N-terminal protection in solid-phase peptide synthesis, enabling reliable coupling and deprotection cycles under standard conditions.

Application

Fmoc-Gly-OH serves as a cornerstone building block in solid-phase peptide synthesis, enabling efficient Nα-protecting group introduction with orthogonal deprotection. Its glycine backbone ensures minimal steric hindrance and high coupling efficiency, while the fluorenylmethoxycarbonyl (Fmoc) group offers stable storage and mild base-labile removal. The carboxylic acid terminus facilitates straightforward activation and coupling to growing peptide chains, making it ideal for synthesizing complex sequences and peptidomimetics with high purity and yield.

Synthesis

Route1
- 28920-43-6
- 56-40-6
- ~87%
- In-stock
  
  29022-11-5
References
- Gawande, Manoj B.; Branco, Paula S. Green Chemistry, 2011 , vol. 13, # 12 p. 3355 - 3359
Route2
- 1370440-28-0
- 56-40-6
- ~93%
- In-stock
  
  29022-11-5
References
- Khattab, Sherine N.; Subiros-Funosas, Ramon; El-Faham, Ayman; Albericio, Fernando Tetrahedron, 2012 , vol. 68, # 14 p. 3056 - 3062
Route3
- 1370440-32-6
- 56-40-6
- ~94%
- In-stock
  
  29022-11-5
References
- Khattab, Sherine N.; Subiros-Funosas, Ramon; El-Faham, Ayman; Albericio, Fernando Tetrahedron, 2012 , vol. 68, # 14 p. 3056 - 3062

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 75.63
LogP 2.6097
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 4

Other Classifications

Life Science Amino Acids and their Derivatives Glycine and derivatives

Life Science Amino Acids and their Derivatives N-protected amino acid

Building Blocks Functional Group Fmoc

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids N-Protected Amino Acids

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Fmoc-Gly-OH

CAS No. 29022-11-5

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