(R)-1-((Benzyloxy)carbonyl)piperidine-2-carboxylic acid

Name: (R)-1-((Benzyloxy)carbonyl)piperidine-2-carboxylic acid
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CAS No. 28697-09-8
Cat. No. CS-0199076
Purity≥98%
MDL No.None

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(R)-1-((Benzyloxy)carbonyl)piperidine-2-carboxylic acid|CS-0199076

Structure of 28697-09-8

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General Information

CAS No. 28697-09-8
Cat. No. CS-0199076
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₁₇NO₄
Molecular Weight 263.29
Synonym(s) 1,2-piperidinedicarboxylic acid, 1-(phenylmethyl) ester, (2R)-
SMILES C1=CC=C(C=C1)COC(=O)N2CCCC[C@@H]2C(=O)O

Description

This chiral piperidine derivative features a benzyl-protected carboxylic acid group, enabling straightforward deprotection and functionalization. The (R)-configuration ensures stereochemical fidelity in asymmetric synthesis, while the benzyloxycarbonyl moiety provides stability and compatibility with standard peptide coupling protocols.

Application

(R)-1-((Benzyloxy)carbonyl)piperidine-2-carboxylic acid serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and peptidomimetics. Its bench-stable Boc-like protecting group facilitates orthogonal deprotection strategies, while the piperidine core supports diverse functionalization. The molecule exhibits excellent compatibility with standard coupling reactions and is well-suited for iterative synthesis workflows in API development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 66.84
LogP 2.2623
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 3

Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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(R)-1-((Benzyloxy)carbonyl)piperidine-2-carboxylic acid

CAS No. 28697-09-8

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