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Structure of 2828444-35-3
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This chiral pyrrolidine derivative features a fluorinated carbon at the 4-position and a methyl group at C2, delivering enhanced metabolic stability and conformational rigidity. The hydrochloride salt form ensures excellent solubility and shelf stability, enabling seamless integration into peptide-based drug discovery workflows.
(2S,4R)-4-Fluoro-2-methylpyrrolidine hydrochloride serves as a stereochemically defined pyrrolidine building block for medicinal chemistry and catalytic synthesis. Its fluorinated C4 position enhances metabolic stability and modulates pKa, while the 2-methyl group provides steric control in asymmetric transformations. The hydrochloride salt ensures excellent bench stability, solubility, and ease of handling, facilitating direct use in amine coupling, reductive amination, and transition-metal-catalyzed functionalizations.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362+P364
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Lot numbers can be found on the outside label of a product: