(2S,4S)-4-Fluoro-2-methylpyrrolidine hydrochloride

Name: (2S,4S)-4-Fluoro-2-methylpyrrolidine hydrochloride
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 2828444-34-2
Cat. No. CS-0626227
Purity≥97%
MDL No.None

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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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(2S,4S)-4-Fluoro-2-methylpyrrolidine hydrochloride|CS-0626227

Structure of 2828444-34-2

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Description

(2S,4S)-4-Fluoro-2-methylpyrrolidine hydrochloride is a stereochemically defined heterocyclic amine featuring a fluorine atom at the 4-position and a methyl group at the 2-position. This configuration imparts enhanced metabolic stability and favorable conformational rigidity. The hydrochloride salt form ensures excellent solubility in aqueous media and facilitates handling in synthetic workflows. It serves as a key chiral building block for bioactive molecules in medicinal chemistry.

Application

(2S,4S)-4-Fluoro-2-methylpyrrolidine hydrochloride serves as a stereochemically defined building block for the synthesis of fluorinated bioactive molecules. Its constrained pyrrolidine scaffold enables efficient incorporation into pharmaceutical intermediates, particularly in CNS-targeted compounds. The hydrochloride salt enhances bench stability and facilitates purification, while the 4-fluoro and 2-methyl groups provide favorable electronic and steric properties for coupling reactions and metabolic stability in drug candidates.

General Information

CAS No. 2828444-34-2
Cat. No. CS-0626227
Purity ≥97%
MDL No. None
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₁₁ClFN
Molecular Weight 139.60
Synonym(s) None
SMILES C[C@@H]1NC[C@@H](F)C1.Cl

Computational Chemistry Data

TPSA 12.03
LogP 1.1281
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(2S,4S)-4-Fluoro-2-methylpyrrolidine hydrochloride

CAS No. 2828444-34-2

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