Fmoc-hLys(Alloc)-OH

Name: Fmoc-hLys(Alloc)-OH
Brand: ChemScene
Availability: InStock
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CAS No. 281655-70-7
Cat. No. CS-0439416
Purity≥97%
MDL No.MFCD01860682

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 281655-70-7

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Description

Fmoc-hLys(Alloc)-OH is a protected lysine derivative designed for solid-phase peptide synthesis. The Fmoc group enables orthogonal Nα-deprotection, while the Alloc moiety provides a stable, removable side-chain protection. This combination supports efficient coupling and selective deprotection under palladium-catalyzed conditions, streamlining complex peptide assembly.

Application

Fmoc-hLys(Alloc)-OH serves as a protected lysine building block for solid-phase peptide synthesis, enabling site-selective incorporation of lysine residues with orthogonal functionality. The Fmoc group provides efficient N-terminal protection compatible with standard deprotection conditions, while the Alloc (allyloxycarbonyl) side chain protection allows for mild, palladium-catalyzed removal under neutral conditions. This orthogonal strategy facilitates selective modification during late-stage diversification, supporting the synthesis of complex peptides and peptidomimetics with high fidelity and minimal side reactions.

General Information

CAS No. 281655-70-7
Cat. No. CS-0439416
Purity ≥97%
MDL No. MFCD01860682
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₆H₃₀N₂O₆
Molecular Weight 466.53
Synonym(s) None
SMILES C(OC(N[C@@H](CCCCCNC(OCC=C)=O)C(O)=O)=O)C1C=2C(C=3C1=CC=CC3)=CC=CC2

Computational Chemistry Data

TPSA 113.96
LogP 4.4509
H_Acceptors 5
H_Donors 3
Rotatable_Bonds 12

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Alanine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-hLys(Alloc)-OH

CAS No. 281655-70-7

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